I can cite a few TV shows that featured women dressing as men; I can also assure you, they were anything but convincing male impersonators. Lucille Bal as "Carrot top Carmachael" a gangster, or Linda Lavin in a similar role. Hooray for me, because I swore-off sitcoms forever!

Did they really think these were funny?
Anyway, back to the point: although there were these and other examples, I do agree that the idea of a woman
needing a male heart to play the role of a male might not be too popular in light of the PC trends.
There is the tragic & I think criminal case of the boy who was born with a very small --. Doctors advised emasculation, dresses, dollies, and female hormones to turn him into a pseudo-female; albeit, one that could never reproduce. Parents agreed and they did to this helpless child worse things than Dr. Mengale ever dreamed of doing. The child grew up, & despite the injections of female hormones, and him having been raised as a girl, he developed a male personality, male sexual desires, etc. Hmm, I wonder why?
Regardless of what people
believe about sex, sexuality, & such, with the exception of brian chemical imbalances and psychological problems, males are & always will be males, etc. There have always been tomboys, but these are still females at heart. Thus, the premise of Sapphire being born with both a female and male 'hearts' is at least somewhat plausible as far as fiction goes.
About cross-dressing, there is a long history of Hollywood having men dress as women, and even some women dressing as men. but the female voices and slender hands are dead give aways. What might irritate the domestic crowd would be a
foreign film featuring the Ribon no Kishi plot.